The National Institute for Health and Care Research (NIHR) is pleased to launch a sixth Research and Innovation for Global Health Transformation (RIGHT) call that will support targeted research to prevent, treat and manage multiple long-term conditions in low and middle income countries.
The NIHR Global Health Research portfolio was established to support applied health research for the direct and primary benefit of people in low and middle-income countries (LMICs) on the Development Assistance Committee (DAC) list, using Official Development Assistance (ODA).
Principles
The Global Health Research portfolio is underpinned by three principles which guide development and delivery. These are:

• Meet eligibility criteria as Official Development Assistance (ODA), i.e. funded research directly and primarily benefits people in ODA-eligible countries on the DAC-list.
• Deliver high-quality applied health research, building on the Principles of the National Institute of Health Research (NIHR): Impact, Excellence, Effectiveness, Inclusion, and Collaboration.
• Strengthen research capability and training through equitable partnerships.
  Aims
  Through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme, NIHR provides research funding to support cutting-edge interdisciplinary applied health research in key areas in ODA-eligible countries where a strategic and targeted investment can result in a transformative impact.
  Building on the NIHR Global Health Research portfolio principles above, the strategic aims across the RIGHT program are to:
• Deliver applied health research for the direct and primary benefit of LMICs, typically through research in key thematic areas for the prevention of ill health and optimal disease management.
• Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers and institutions involved in the research.
• Promote interdisciplinary approaches to working (including, but not limited to: clinical medicine, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered.
• Generate new research knowledge and evidence on interventions to improve health outcomes of people in LMICs.
  Priorities
  NIHR is seeking applications for RIGHT Call 6 that focus on the development and evaluation of interventions and strategies for improved prevention, treatment and management of multiple long-term conditions, including:
• Interventions to prevent stepwise progression of MLTCs once one long-term condition or infection has been diagnosed
• Interventions to improve treatment, management and care of patients with infections prevalent in LMICs that have a known association with development or exacerbation of NCDs
• Interventions for the treatment and prevention of the development of MLTCs in children and young adults driven by malnutrition, multiple chronic infections and poverty
• Scalable treatment and care approaches that integrate the management of MLTCs/disease clusters associated with infection(s) and/or NCD(s)
• New treatment packages, new models of care and community-based interventions
• Healthcare systems strengthening: research into health care system improvements for treatment, management and care for those affected by MLTCs in LMICs may be included as a component of the research.
• Research that leads to a better understanding of risk factors, cultural attitudes and practices influencing the development of MLTCs can be included provided it is part of a wider program of work contributing to the implementation or evaluation of one or more interventions.
  In recognition that the COVID-19 outbreak continues to impact global health systems, applicants should consider the context of COVID-19 where relevant to their research proposal, both in terms of project planning and the generalisability of outcomes.
  Funding Information
• Through this call, awards up to £5 million, range £1-5 million (maximum of £5 million) over 3-5 years are available for eligible research. Applications in the lower part of this range are welcomed where smaller programs will still address the aims of the call.
  Eligible Costs
  Eligible costs for NIHR RIGHT calls include:
• Direct Costs
• Staff costs
• Travel, Subsistence and Conference costs
• Equipment
• Consumables
• Community Engagement and Involvement
• Dissemination
• Risk Management and Insurance
• Training and Development Costs
• External intervention costs
• Monitoring, evaluation and learning
• Other Direct Costs
• Indirect Costs / Overheads (guidance varies according to type of organization).
  Eligibility Criteria
• Leadership models can be either:
  - LMIC-led: A Principal Investigator (Lead Applicant) employed by an LMIC Higher Education Institution (HEI) or Research Institute.
  - LMIC-UK Joint Leads: A Principal Investigator employed by a UK HEI or Research Institute (UK Joint Lead Applicant) to jointly lead with a Principal Investigator employed by an LMIC HEI or Research Institute (LMIC Joint Lead Applicant).
• Applicants to state which will be the contracting institution.
• Where the contracting organization is a UK institution with a UK Joint Lead Applicant, it is mandatory for an LMIC Joint Lead Applicant to be included on the application, with the expectation that the joint leadership/partnership is equitable.
  Where the contracting organization is an LMIC institution, a UK Joint Lead Applicant is not a mandatory requirement. LMIC Lead Applicants may propose joint leadership partnerships with a Principal Investigator from another eligible LMIC or UK institution, or lead the application without a Joint Lead Applicant.
• The contracting institution must be a HEI or Research Institute. An LMIC or UK Research Institute is considered to be a not-for-profit research organization with a proven track record in the field or discipline in which it is applying for funding, and sufficient research and financial capacity to manage and deliver research and training.
• For organizations that have not previously been funded by NIHR Global Health Research funding, additional eligibility and due diligence checks may be undertaken in addition to standard NIHR eligibility and due diligence checks prior to contracting.
• Depending on the nature of the partnership, there may be other affiliated Co-applicants and collaborators/project partners including service level providers. No limits will be placed on the number of Co-applicants/Collaborators necessary to effectively deliver the aims of RIGHT awards.
• Under this call, an individual cannot be named as Lead/Joint Lead Applicant on more than one application.
• There are no restrictions on the number of applications an institution can submit under this call provided they are distinct in their objectives.
• Existing NIHR Global Health Research award holders are eligible to apply to this call provided there is assurance they have sufficient plans in terms of time and resources available to them to deliver concurrent awards successfully.